Testosterone replacement therapy improves survival in diabetic men with low testosterone levels
Two studies examining the effects of low testosterone in diabetic men indicate that low testosterone is associated with poor health-related quality of life and that testosterone replacement therapy can improve survival. The first study analyzed total testosterone , bioavailable testosterone and sex hormone-binding globulin levels in morning blood samples from 356 men with diabetes , 126 of whom also completed an International Index of Erectile Function Score questionnaire. TT levels significantly correlated with HRQoL when corrected for SHBG. IIEF scores significantly correlated with TT , BT and free testosterone . In the second study, 578 men with diabetes who had TT performed between 2002 and 2005 and were followed up for 5.8 years, were analyzed in three groups: i) normal TT , ii) low TT without TRT and iii) low TT with TRT . Survival was significantly improved in patients with low testosterone who underwent TRT 2011] 2011, 25: Abst P152; Muraleedharan, V. et al. Endocr Abstr [Soc Endocrinol BES 2011 2011] 2011, 25: Abst P163).
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