Inflammation and poor glycemic control interact to affect cognition, leading to dementia
Evidence on the link between diabetes mellitus and Alzheimer’s disease is increasing, with a strong indication that inflammation is a major common denominator. The associations between glycemic control and inflammation and their effect on cognitive function were investigated in a longitudinal single-center study. A total of 584 patients with diabetes who were dementia-free at baseline were included. Glycemia was based on hemoglobin A1c and inflammation status on the biomarkers C-reactive protein and interleukin-6 . Cognitive status was calculated using Z-scores of overall cognition and four apriori cognitive domains memory, language, attention and executive functions. Partial correlations were calculated, controlling for age, gender, educational level and DM duration. Mean age, education and DM duration were 72, 12.3 and 8.3 years, respectively. Levels of HbA1c and inflammatory markers were not associated with cognition. However, CRP had significant interactions with overall cognition and the four cognitive domains measured. The results showed no direct associations between HbA1c and inflammatory markers with cognitive function. Nevertheless, elevated CRP levels adversely affected cognition and its different domains, suggesting that the deleterious effect of poor glycemic control on cognitive function may depend on the degree of inflammation 2011, Abst P4-332).
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